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The evolution of powered wearables has been exciting to watch, evolving from clunky and with limited application to sleek and multipurpose. For those that have been following SRI‘s development of Superflex, there has been some wait to see the development of the soft wearable exosuit.

With the termination of Superflex and the acquisition of Lumo Bodytech by SRI comes the strength of the new SRI-sponsored company Seismic. Seismic is a new product which integrates technology from Superflex and movement-based algorithms from Lumo Bodytech to assist with human movement with a soft robotic exosuit.

For anyone along the aging population spectrum, powered wearable technology will provide independence and support to sustain daily activities and exercise. Thankfully due to progress in wearables, the appeal is growing to the mass market for application of common tasks.

The most appealing wearables are those that are easily integrated into a user’s life without many additional steps. Can a person integrate the wearable into their daily routine without thinking too much about activating or wearing the product? Passive integration is generally best.

The robotic design integrated into Seismic’s wearable gear facilitates easy enhancement of movement and activities. A person can simply slip on the gear, and activate the desired function. The gear complements the muscular activity which is the source of our movements.

For those following the evolution of wearables, Seismic provides a pathway to the integration of wearable robotic gear to improve everyday activity.  Movement and mobility mean independence, and for those that need a little extra assistance, this type of wearable will be a lifechanger.

After working for years in different healthcare settings, I learned to appreciate simple, good design of medical products, and have experienced the frustration of poor design.

Most of the time we use a medical product is for an important reason, often putting the function of the product before the design in importance. However, this model of function before design often leads to unforeseen problems from misuse.

One of the most important factors for whether a product will be adopted is whether the intended user can actually use the product, and how easily. Even if something is a major engineering accomplishment, if it is difficult for a patient or provider to use it will either be misused or not used at all. Misuse due to confusion and poor design lead to poor adoption.

Below are some frequently used medical products, categorized by quality of design.

Good Design: Pulse Oximeters

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A pulse oximeter is a small medical device to measure the oxygen saturation in a person’s bloodstream. Typically in a hospital setting, you want oxygen saturation to be above 92%. Lower values mean a person is not getting enough oxygen, and this can result in fainting, falling, and other risks.

The reason that pulse oximeters have a good design is the ease of use. One simple inserts their finger into the device, which then reads the oxygen saturation using infrared light through the capillaries in the hand, and displays the reading on an easy to read screen.

There is little confusion about how to use this device, and little confusion about how to read the result.

Poor design: Most Wheelchairs

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Having worked extensively with individuals using wheelchairs, there are very few which have been properly adjusted or fitted for people. Manual wheelchairs by design are difficult to adjust, both for patients and healthcare professionals, leading to frustration and improper fitting and use. In the rush of an injury such as sudden paralysis,  people are often improperly fitted and rushed into buying a wheelchair which does not suit them.

Manual wheelchairs have multiple parts, which can be difficult to adjust and store. Additionally, the weight of the product creates a burden on users, especially with repetitive use. Lightweight models made of carbon fiber have begun to address these issues, but the price remains high for many people to afford.

For the amount of years wheelchairs have existed in healthcare and been an option for those with limited mobility, there is still a long way to go before wheelchairs become an easily used product for short or long term use.  

Improving Design: Prosthetics

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Prosthetics, particularly for below knee amputees, is one area of healthcare which has significantly improved in the last couple of decades. Companies have adopted modular designs for fit, comfort, design, and safety. Compared to the wooden, heavy prosthetics of 20 years ago, new prosthesis allow individuals to walk and run. 

The true beauty of improvement in prosthetics is being brought to surface by research labs such as Hugh Herr’s lab at MIT, where projects are breathing new life into  prosthetics with added function, mobility, and proprioception.

 

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The term “ergonomics” normally has a similar effect on people as the words “healthy lifestyle:” guilt and unattainability. It conjures the image of someone sitting stick straight at a desk or lifting a box like a robot. We hear about it, know we should follow it, and ultimately dismiss it due to inconvenience.

One of the main lessons I learned from treating hundreds of people with work-related injuries is that unless there is a very traumatic injury, it is normally repetitive stress which wrecks our bodies. Our bodies are designed for a variety of functions which are often not physically accommodated in most jobs. Arms are designed for manipulation during a variety of daily tasks, not for constant daily typing. Our legs are designed to alternate loads during walking, and not for prolonged standing or repetitive squatting in place. Our torso muscles and spine developed to hold us upright during walking, and prolonged sitting has known deleterious effects1.

When I started doing ergonomic evaluations, I would normally sound off about 10 ideal postures and mechanics to which people would politely nod and then forget about.

In knowing the importance of correct body mechanics and trying to make ergonomics accessible, I found two simple rules can help people decrease the risk of potential strains and sprains:

Keep frequently used items close to your body

The further away from your body an object is, the less efficient your muscles are and the risk of strain increases. Keep frequently used items “bent elbow” distance from your body. 

Change positions frequently

Our muscles fatigue when trying to hold us in place for prolonged periods. One way to break up this fatigue and allow some recovery time is to alternate positions.

If you can’t keep close items which you’re working with, and you must perform repetitive tasks for your job, then enlisting assistance is a good idea. An exoskeleton which passively assists during repetitive squatting, repetitive overhead lifting, and repetitive bending helps during those tasks when our body is vulnerable to injury.

 

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How is it really that a person can learn to move again after a debilitating injury? When a neurological injury such as a stroke or spinal cord injury occurs, people are left wondering how to function again. It can seem like the end of movement as they know it, a death in the way that a person has adapted to navigating their environment for years.

Depending on the type and severity of a neurological injury, the results of such an event can vary greatly. A brain injury such as a stroke disrupts the way that the brain serves as a command center for muscles, altering the way a person has learned to move and feel. A traumatic brain injury can completely alter movement, perception, and personality, depending on the area of the brain affected. Degenerative diseases such as Multiple Sclerosis slowly attack a person’s central nervous system, causing them to have a gradual decline in physical and sensory function.

In physical therapy, clients and their families are understandably scared and frustrated after such injuries. How does a person move forward with a life-changing disease or event? The hope lies in the power of adaptation, and the ability of the human neural circuitry to rewire and allow someone to learn to navigate the world in a new way. This is called neural plasticity, and it is a powerful survival tool which optimizes our resilience in life.

The nerves in our bodies communicate with biological electrical signals much like common electrical wires. When one nerve wire is faulty, our body finds a way to establish a signal through a new route so that a message can be delivered. This is absolutely amazing, and allows people to move forward in life after a debilitating disease or injury.

People often wonder how long it will take until they feel ‘normal’ again, and the beauty of neural plasticity is that our bodies find a new ‘normal’ through rewiring the neural circuitry. The key in this recovery is that the body and brain must be forced to find the new normal through practice and repetition. Encouraging someone to use their arm after a stroke, for example, fosters new signals in the body which recover upper body movement. Practicing walking after a stroke is vital in recovering walking ability.

The central nervous system recovers by creating new synapses. Where there was a blockage in communication from the injury, new receptors and new active signals are created. This requires increased stimulation in the brain, meaning that a person must be encouraged to do an activity which may seem difficult and new given their injury. It will initially feel like a new, uncoordinated task and will slowly become more efficient with practice as the brain and central nervous system adapt.

Peripheral nerves, the ones that transmit signals from the spinal cord to the rest of the body and back, also recover in several ways. The tail of the neuron, the axon, can regrow. In addition, a number of events are set off to create new signals and stimulate recovery.

Neuroprosthetics and technologies that force a person back into movement early may stimulate this mechanism of neural plasticity for an injured person. In general, the sooner that someone can start moving, the better. More time without movement means more muscle atrophy, as well as more of the body forgetting how to move through disuse.

The body responds to the commands and stresses that are placed on it, and devices and therapies that foster a plastic response are not only positive and productive, but what allow people to survive and adapt after a life-changing injury.

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Pneumonia is a potentially fatal infection of the lungs, causing them to accumulate fluid in the air sacs. Especially dangerous for the very young, old, and immunocompromised, it must be diagnosed and treated as quickly as possible. Currently, the gold standard for diagnosis is a chest x-ray, which is not only inconvenient and costly, but also exposes an individual to radiation.

A staple physician accessory has always been the stethoscope, a tool for amplifying sound when listening to the internal sounds of a patient. When a doctor is listening to your heart or lungs, this requires a combination of skill with placement and auditory detection to differentiate normal and abnormal sounds. This alone is not enough to diagnose a lung infection such as pneumonia, and thus a suspected diagnosis must be confirmed with an x-ray.

A new instrument looks to improve the accuracy and ease of diagnosing pneumonia while providing an inexpensive and convenient alternative to chest x-rays. Tabla works by streamlining a series of simple steps to detect possible lung infections. A provider places the device over a patient’s sternum, and then continues to move the stethoscope around known areas of the lung while a wireless app collects diagnostic data.

As medical instruments become digitized for accuracy, interpretation of patient data and output is becoming more standardized. Tabla is a brilliant device which not only streamlines the diagnostics process for lung infections, but eases the burden of cost and minimizes exposure to radiation in the treatment of pneumonia.

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One of the great challenges in biotechnology is interfacing synthetic materials with biological ones. Our bodies are designed with an extremely complex network of tissue, vascular, and neural structures to protect us and alarm us if there is something potentially dangerous to our system. If we sit for too long, for example, we feel discomfort and shift positions instinctively. If something is pressing against our leg and threatens to disrupt normal blood circulation, we perceive this threat with pain and pressure and respond accordingly.

Amputees and prosthetists have long been facing the issue of how to interface the residual limb with a prosthetic socket. Fitting for a prosthesis introduces a synthetic limb component to a biological one, and an improperly fitted socket can cause pain, pressure sores, and expose a residual limb to infection and tissue damage. And while there has been much improvement from the crude iron prosthetics that amputees once had to endure, there is still much room to improve to make the interface closer to a natural one.

One group at MIT has sought to address this disparity by developing a variable impedance prosthetic (VIPr) socket. Using MRI imaging and surface scanning techniques, researchers were able to find the tissue depth and where the socket was most likely to place pressure on the irregular bony areas of the residual limb. A socket was then 3D printed using this data to apply the least amount of pressure when fitted to the amputee.

After testing this socket on a below knee amputee, it was found that there was a 7-21% decrease in pressure on various bony areas of the leg compared to a regular socket during walking. While there is still no perfect socket or prosthetic interface for amputees, this is a step in the right direction to protect valuable and vulnerable human tissue.

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Regenerative medicine using biotherapy and bioprinting is providing much hope for previously irreversible conditions such as burns, muscle damage, and cancer. Cells and cellular environments are extremely difficult to reproduce once they are damaged, and much of regenerative medicine focuses on how to repair what our bodies originally made so easily.  3D cell production, versus 2D cell production, mimics the organic environment of our bodies to produce cells. In biotherapy, living organisms are used as the starter in this process.

The complexity in the specificity of our cells is part of why it is so difficult to reverse cell damage. Thus, stem cells are valuable biological material due to their ability to differentiate into any type of cell based on their environment and genetic factors. A stem cell starts out as a blank slate, and by receiving environmental and genetic signals, can become virtually anything in the human body, from a kidney to a blood cell to a muscle in the leg.

Placental stem cells are organically derived and the natural byproduct during a birth. Instead of being discarded, they can provide a very important product for placental cell therapy, which helps direct cells toward regeneration and promotes healing. In biotherapy, these placental stem cells can be very valuable for the cell production process.

Pluristem, a company quickly gaining international presence, produces 3D cultured placental stem cell therapies for various conditions. The company uses a 3D platform to produce their line of PLX products, mimicking the environment of the human body for cell production. This cell therapy is developed to provide cell therapy which is easy to use and does not require genetic or tissue matching. Once the therapy is administered, it promotes the body to heal itself in the target area.

Pluristem products provided regenerative therapy for a variety previously potentially irreversible conditions. Among these is acute radiation syndrome (ARS), which involves irreversible damage to organs and bone marrrow from radiation exposure. Pluristem also aims to provide therapy for vascular conditions such as critical limb ischemia, intermittent claudication, and pulmonary arterial hypertension, all which are dangerous and can lead to decreased life span or surgery.

Pluristem is currently in its clinical trial phase, with collaborations with several universities and industry partners, including the NIH.

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